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The controversy is due to their mitogenic activity, or their ability to increase the number of cells

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It was also concluded from a study that GST pathway in mice and rats were more active than that of humans and hamsters

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Blood samples were collected from the chest cavity, and rats were perfused transcardially with 60 ml of 0.9% saline followed by 120 ml of 4% paraformaldehyde (Sigma-Aldrich)