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Epitalon (also known as Epithalon) is a synthetic tetrapeptide consisting of four amino acids: Alanine Glutamic Acid Aspartic Acid Glycine It was developed based on naturally occurring peptides produced by the pineal gland, an endocrine gland located in the brain that plays a crucial role in regulating circadian rhythms, melatonin production, aging, and hormonal balance

The main negative regulator of NF-B activity is zinc finger protein (A20), which is known as a cell protector against TNF--induced NF-B toxicity, decreasing its level, along with IL-1

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Although it may be slightly less toxic than the interferons, Copaxone has a fierce adverse effects profile

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Furthermore, lutein could prevent osteoporosis by its antioxidant effects, regulation of bone formation and bone resorption, and reducing the differentiation of osteoclasts