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Oct 16 2012;46(20):11313-8
ROS are detoxified by the antioxidants present, mainly ascorbate
The assessment of placebo groups in randomized controlled trials for melasma allows for measuring the efficacy of broad-spectrum tinted sunscreens, accounting for a 1020% melasma area and severity index (MASI) reduction in 8 weeks [19]
Protein purity was assessed by SDS-PAGE, and their concentrations and 260/280 nm absorbance ratios were determined using a NanoDrop spectrophotometer (Thermo Scientific)
ABC transporters also show high expression levels in tissues involved in excretion/detoxification (e.g., liver and kidneys), or acting as barriers (gut epithelium, capillary endothelia forming the blood-brains barrier, epithelial cells...) mediating the cellular efflux of a diverse array of chemicals and some metals and limiting chemical uptake
This lack of information currently limits clinical studies
