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Management includes increased fibre intake, adequate hydration, proper toilet habits, and gradual dose escalation under medical supervision

This includes rotating injections and not always injecting at the same site each time to minimize the risk of irritation and pain at the site

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In histology, all kidney tissues from the mice treated with colistin showed elevated expression of the AKI markers Ngal and Kim-1, tubule dilation, loss of the brush border membranes in the proximal tubules, and the formation of protein casts throughout the kidney tissue, indicating vast tubular damage (Fig