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21 Additionally, vagal nerve afferents carry sensory information from the gut directly to the NTS

Adjusting the dose, switching peptides, or stopping treatment are valid responses based on clinical judgment

In Part B, drug safety and the change in fructosamine levels from baseline were evaluated as secondary objectives

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However, when fatty acid delivery exceeds mitochondrial oxidative and redox-buffering capacity, increased electron transport pressure can elevate reactive oxygen species (ROS) production, promote endoplasmic reticulum stress, and increase susceptibility to lipid peroxidation [54, 61,62,63]