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Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc

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39 FDA will also almost certainly continue to monitor websites, online labeling, and marketing materials, as we saw this year, and issue warning letters citing unapproved drug charges (for both COVID- and non-COVID-related products)