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HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription

Diet composition appeared to account for several of the observed microbiome differences

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Olsvik et al., 2017)

Prescribers can adjust hydroquinone beyond the commercial 4% ceiling (up to 8% for refractory cases), swap the steroid component based on patient sensitivity, add tranexamic acid or cysteamine for resistant pigmentation, and choose vehicle bases optimized for different skin types and climates