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Two once-weekly injectable peptides have come to define the modern conversation about pharmacological weight loss: tirzepatide , an approved dual GIP/GLP-1 receptor agonist, and retatrutide , an investigational triple GcGR/GIP/GLP-1 agonist that adds glucagon-receptor activity to the same incretin backbone

Neuroscience 137 , 8392 (2006)

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