At this stage, it is extremely important to underline the role played by the intestinal microbiota: the biotransformation reactions of polyphenols in vivo , - i.e., sulfoxide reductase, nitro reductase, glucuronosyltransferase - are all microbial enzymes [53-54] and, consequently, microbiota community composition can greatly influence their function [55]
512 In a myocardial I/R injury model induced by coronary artery ligation, inhibiting ferroptosis led to a reduction in infarct size and enhancement of left ventricular systolic function
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METs and M1 polarization formed a positive feedback loop in kidney injury To further elucidate the critical role of NIK/NF-B2 and METs in CaOx-exo-induced kidney injury, we used METs inhibitor CI-amidine or NIK inhibitor NIK SMI1 to suppress METs production and NIK/NF-B2 pathway in mice, respectively
L., Sailaja, E., Rao, A