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As key enteroglucagons, GIP and GLP-2 themselves exhibit excellent hypoglycemic properties ( 4.1.4 Gutbone axis and periodontitis Periodontitis is a chronic infectious disease caused by periodontal pathogenic bacteria, which stimulates the differentiation of osteoclasts while inducing periodontal inflammation, resulting in alveolar bone resorption ( 4.1.5 Braingutbone axis The human body is functionally interconnected as a whole, and thus, synergies between the gutbone axis and other organs in terms of mechanisms are also predictable

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Motor symptoms, measured by the MDS-UPDRS, improved with a mean decrease of 8.7 (11.8) points (95% CI, -15.3 to -2.2