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In this colon cancer model, melatonin decreased the levels of inflammatory markers IL-6, IL-17, TNF-, NF-B, COX-2 and STAT3, as well as reduced DNA damage and OS indicated by reduced TBARS and increased GSH levels ( Supplementary Table 1 )

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After being phosphorylated, AKT participates in important biological processes such as apoptosis, protein synthesis, and cell cycle progressionAfter being phosphorylated, AKT participates in important biological processes such as apoptosis, protein synthesis, and cell cycle progression