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The Warburg effect, characterized by aerobic glycolysis, is closely linked to the onset and progression of tumors and promotes lactate production
Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease
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Genetic differences and aberrant methylation in the apelin system predict the risk of high-altitude pulmonary edema