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Effectiveness and Weight Loss Outcomes Head-to-head comparisons show GLP-1 medications like semaglutide generally produce greater weight loss than Contrave

Psychiatry 36 , 289292 (1979)

All study participants were randomly assigned to an experimental treatment group that received subcutaneous injection of cagrilintide, once-weekly, in doses of either 0.3, 0.6, 1.2, 2.4, or 4.5 mg, as well as a one-daily 3.0 mg dose of liraglutide, and a volume matched placebo for control purposes

LK and ZX performed the experiments and wrote the manuscript

in fact, their weight reduction was less pronounced than that of those on the lower dose

Some patients require lower starting doses to minimize nausea