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Slower dose titration and dietary guidance (smaller, more frequent meals, avoiding high-fat foods) effectively mitigate these symptoms in most patients

Contraindications and cautions : Be aware of specific situations where one or both medications should be avoided or used with extreme caution: Pregnancy : Both medications should be avoided in pregnancy

Always consult a licensed clinician before starting, stopping, or changing any medication

In its Complete Response Letter, the FDA stated that the application did not provide substantial evidence of effectiveness to support its approval and that further research would be required

Relatively safe: When used correctly and under medical supervision, most medications have manageable side effects

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