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Improvement in pain-free walking distance (ICD) was also greater for PLC than for placebo, with a mean difference in absolute improvement of 32.98 meters (95% CI 32.60 to 33.37
Common Deficiency Warning Signs: B12 deficiency often develops gradually, making symptoms easy to dismiss initially
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Starting dose (adults): -thalassemia: 1 mg/kg once every 3 weeks
Oral bioavailability is limited due to enzymatic breakdown in the gastrointestinal tract, yet some studies show systemic benefit at doses of 5001500 mg daily
Bariatric surgery remains an option for patients with severe obesity who meet specific NICE criteria generally a BMI of 40 or above, or 35 or above with significant comorbidities, with lower thresholds applicable in some groups, such as those with recent-onset type 2 diabetes
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