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however, evidence suggests that this resistance is mediated by compensatory increases in whole-body GLP-1R signaling (105), and increased islet GLP-1 production (105, 106)

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Rahbar AR, Shakerhosseini R, Saadat N, Taleban F, Pordal A, Gollestan B: Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus

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