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Tretinoin can cause temporary dryness, flaking, or purging during the adjustment period (niacinamide often helps minimize this)

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Key genes associated with this response are listed in Table 3A

PCs can also function as important chelators of Zn ions (Tennstedt et al., 2009)

Blood pressure was manually checked during the initial in-clinic doses and continuously monitored via 24-hour ambulatory BP measurement (ABPM), with readings taken every 15 minutes

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