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5ad) and had no acute or chronic effect on mitochondrial functions in differentiated BAT primary cells, including mitochondrial respiration, proton production rate, proton leak respiration, coupling efficiency, maximal substrate oxidation, cellular respiration, non-mitochondrial and mitochondrial respiration, ATP-linked respiration, glycolysis, glycolytic proton production rate and glycolytic and oxidative phosphorylation-linked ATP production (Extended Data Fig

We thank Luise Bolther for technical assistance

Selenium metabolism and OA Physiological significance of oxidative stress in chondrocytes OA is the most common form of arthritis and is primarily characterized by the loss of cartilage-specific ECM and other pathological changes in joints including subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31

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Those with a loose sphincter muscle between the stomach and esophagus frequently experience increased reflux on GLP-1 meds

Current guidance from US medical societies emphasizes a risk-stratified approach rather than universal medication holds