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Kidney disease The issue Roughly one in three adults with Type 2 diabetes also has chronic kidney disease, which occurs when the kidneys are damaged and cant function properly

MajewskaMDDemirgrenSLondonED

According to the SmPC, these include: Nausea (very common, affecting more than 1 in 10 people) Diarrhoea (very common) Decreased appetite (common, affecting up to 1 in 10 people) Vomiting (common) Abdominal pain (common) Abdominal distension (common) Constipation (common) Dyspepsia (common) Flatulence (common) These gastrointestinal effects typically occur during the initial weeks of treatment and often diminish as the body adjusts to the medication

Dietary interventions aimed at increasing the production of SCFAs have gained prominence because of the strong correlation between CKD and microbial dysbiosis [176]

Yu J, Thomas PV, Sciacca M, Wu C, Liu J, He X, et al

Others may notice constipation due to slower overall gut transit time