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The reviewer JX declared a shared parent affiliation with the authors LKZ, FX, XZ, LDZ and MW to the handling editor at the time of review

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In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role

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