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Hemorrhagic transformation occurs through a disruption in tight junction proteins, and investigations into this underlying mechanism found that dysregulated extracellular proteolysis in the vascular matrix after tPA contributes to hemorrhagic transformation (Chandler et al., 1990

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mGIPR-Ab treatment had no impact on fat mass (Extended Data Fig

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This usually makes an antipsychotic withdrawal the most challenging of all drug classes, including the difficulties of withdrawal from heroin and benzodiazepines

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