Researchers rely on this documentation because impurities or degradation products can introduce confounding variables into a study, making results difficult to attribute to the compound being tested
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High-dose supplementationparticularly intramuscular injections that can deliver 1,000 micrograms or morecreates substantially elevated serum B12 levels compared to dietary intake, which may more readily trigger these bacterial changes, though comparative studies between different forms are limited
Taking too much can cause side effects like nausea, headache, dizziness, and, in some cases allergic reactions
mcg and mg are units of measurement
[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%
