Staying Ahead of the Change The companies and brands that innovate in anticipation of the impact of these drugs will find themselves awash in new interest from those who feel a new sense of control and autonomy in their choices: brands that speak to their aspirational selves, affirm their commitments to living better, and underscore that behavior-modifying medications are only step one of a lifelong shift that includes their category and brand
doi: 10.2337/db17-1212 41 FarahLXValentiniVPessoaTDMalnicGMcDonoughAAGirardiAC
For midlife women, who may already be managing multiple chronic conditions or navigating metabolic changes tied to menopause, the buzz around GLP-1s may raise questions: Could these drugs help with overlapping health challenges
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Owing to its -helical binding conformation, GLP-1 stroke us as both a good model for testing -helix mimicry with oligourea foldamers and a relevant pharmaceutical target
However, the challenge with current TRPV1 antagonists lies in their associated adverse effects, such as hyperthermia 24,25,26,27,28,29,30,31 and hypothermia 32,33,34 , caused by failures in thermoregulation