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Description

Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies

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International Journal of Molecular Sciences , 23 (5), 2717

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Free Radic Biol Med , 50: 874882, 2011

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From this synthesis, we propose restoration of copper balance using copper delivery agents in combination with chaperones/chaperone mimetics, perhaps in conjunction with the neuroprotective amino acid serine, as a promising strategy in the treatment of this incurable disease

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Wortmannin, a PI3K inhibitor, was unable to suppress RSL3 mediated cell death in RAS and TERT -expressing cells 26

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