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Safety & Tolerability Safety data limited to preclinical research

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Transwell assay The chemotactic motility of HUVECs was determined using transwell migration chambers (Corning) with 6.5 mm diameter polycarbonate filters (8 m pore size), as described previously

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Zhang T, Hu L, Tang JF, Xu H, Tian K, Wu MN, Huang SY, Du YM, Zhou P, Lu RJ, He S, Xu JM, Si JJ, Li J, Chen DL, Ran JH (2021b) Metformin inhibits the urea cycle and reduces putrescine generation in colorectal cancer cell lines