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Both in vivo and in vitro studies have confirmed that FGF21 treatment reduces mitochondrial ROS levels, restores MMP and ATP production, and mitigates neuronal death following TBI

Diabetes Technol Ther 2016;18:14450

Taurine, another critical amino acid, supports osmoregulation by aiding in cellular hydration and electrolyte balance, which is especially required during environmental stressors such as salinity fluctuations

Gastrointestinal symptoms typically improve over time as the body adapts to the medication, though the timeframe varies between individuals

Furthermore, it was stated that clinicians must consider treating patients with T2D and NAFLD with PIO, GLP-1R agonists or sodium-glucose co-transporters 2 (SGLT2) inhibitors to reduce their significant cardiovascular risk