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In 1998, the Swiss company Hoffmann-La Roche (henceforth Roche) manufactured 3000 t/annum riboflavin via chemical synthesis

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(2018) indicated that the gut microbiota of patients with immune-mediated inflammatory diseases such as IBD, ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematosus differed sharply from normal controls

Willems P, Claes K, Baeyens A, Vandersickel V, Werbrouck J, de Ruyck K, Poppe B, van den Broecke R, Makar A, Marras E: Polymorphisms in non-homologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity

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