kidney stones and glp-1 Glucagon-like peptide-1 receptor agonists in diabetic disease: A review of their kidney heart protection The boom in GLP1 drugs

Primary mechanisms of action include: Enhanced insulin secretion : GLP-1 receptor agonists stimulate glucose-dependent insulin release from pancreatic beta cells, meaning insulin secretion increases when blood glucose is elevated but not when glucose levels are normal or low, reducing hypoglycemia risk Suppressed glucagon secretion : These medications inhibit glucagon release from pancreatic alpha cells, decreasing hepatic glucose production Delayed gastric emptying : GLP-1 receptor activation slows the rate at which food leaves the stomach, moderating postprandial glucose excursions Central appetite regulation : GLP-1 receptors in the brain, particularly in areas controlling satiety and food reward, are activated, leading to reduced appetite and caloric intake These combined effects result in improved glycemic control in patients with type 2 diabetes and significant weight loss in both diabetic and non-diabetic individuals

Potential Allergens: Maltodextrin can cause problems in people with severe intolerance to corn or wheat, raspberry flavor may contain traces of allergens and cause rare allergic reactions, plant extracts (ashwagandha, St

Trulicity (Dulaglutide): Trulicity, another once-weekly GLP-1RA, is indicated for both type 2 diabetes management and weight loss

But, theres one side effect thats become harder to ignore: Ozempic Face. As patients lose weight rapidly, especially in the face, many notice deflated cheeks, sagging jawlines, and fine lines that seem to appear overnight

Because gastric emptying is already slowed, adding large amounts of fiber (particularly fermentable fibers like those in beans, lentils, and cruciferous vegetables) can worsen bloating and gas dramatically

Weight regain typically begins within 24 weeks and accelerates over 36 months