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1 Introduction Osteoarthritis (OA) is among the most prevalent degenerative joint diseases globally, affecting more than 500 million people worldwide and ranking as the leading cause of disability among adults aged 50 years and older ( Ferroptosis, first reported in 2012, is a novel form of cell death distinct from classical apoptosis, pyroptosis, and necrosis ( Due to the possible critical role of ferroptosis in OA, there has been a surge of interest in elucidating its molecular mechanisms and exploring potential therapeutic strategies

Moreover, Erastin can increase intracellular iron availability by upregulating heme oxygenase, which releases iron by degrading heme (37)

Rapid weight reductioncommon in the first months of treatment with these medicationsmay not allow sufficient time for physiological adaptation

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The Standard Spectrum of Healthy Urine Healthy urine is typically pale yellow and clear to slightly cloudy

doi:10.1016/j.phrs.2018.02.015