Here we studied the effects of semaglutide on the circulating proteome using baseline and end-of-treatment serum samples from two phase 3 trials in participants with overweight or obesity, with or without diabetes: STEP 1 ( n = 1,311) and STEP 2 ( n = 645)
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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used to improve glycemic control in type 2 diabetes mellitus, manage obesity, and reduce the risk of major adverse cardiovascular events in select adults
A body composition test distinguishes between fat mass, lean muscle, and body water
Patients should work closely with their healthcare provider to implement alternative diabetes management or weight maintenance strategies before stopping semaglutide
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