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Fermentation of fiber by gut bacteria also produces short-chain fatty acids that directly stimulate L-cells

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We highlight the contribution of different cell types to skin repair, with emphasis on how both innate and adaptive immune cells in the wound inflammatory response influence classically studied wound cell lineages, including keratinocytes, fibroblasts and endothelial cells, but also some of the less-studied cell lineages such as adipocytes, melanocytes and cutaneous nerves

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Investigation includes plasma free metanephrines or 24-hour urinary fractionated metanephrines, with urgent endocrine referral required due to potentially life-threatening complications