In fact, empirical evidence would seem to point to a potential weakness of the Reed-Nijhout model, that it ought to be modified to incorporate a higher Met blood leak
Nikiforov, A., Dlle, C., Niere, M
[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Harville E.W., Lewis C.E., Catov J.M., Jacobs D.R., Gross M.D., Gunderson E.P
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