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Most incretin-based compounds target only the first two the addition of glucagon receptor agonism distinguishes this compound in research settings
Individual clearance varies based on body composition, kidney function, and liver function, but the Phase 2 trial established the mean half-life at approximately 6 days for the once-weekly subcutaneous dose range of 0.5mg to 12mg
N Engl J Med 389(6):514526 Muller TD et al (2022) Anti-obesity drug discovery: advances and challenges
While the peptides activation of ENC-alpha in the lungs is a good thing in pneumonia where fluid literally interferes with breathing, the investigators were concerned that activating ENaC-alpha in the kidneys might disturb normal sodium retention, which is important to the kidneys role in blood pressure regulation
doi: 10.3390/nu13030953 61 GuoDHendryxMLiangXMansonJEHeKVitolinsMZet al
More specifically, Bhagavathula and colleagues pooled efficacy outcome data in the same analysis irrespective of type of comparator (placebo or GLP-1 RA) [26]
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