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after 3 months of treatment, notable improvement was noted on right side in the form of decreased shades of pigmentary network (in cases of epidermal melasma) and decreased irregularity of pigmentary network, decreased number of granules and globules (in cases of mixed melasma)

The manufacturers in animal studies have said that there could be adverse outcomes

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More specifically speaking, the mechanism potentially involved downregulation of macrophage CD11b, which played a vital role in monocyte adhesion, as well as decreased expression of macrophage modulators including CXCL-10, CXCL-1, C-C motif chemokine ligand-1 (CCL-2) and tissue inhibitor of metal protease-1 (TIMP-1) (Robinson et al., 2015)