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Appetite Fluctuations Since tirzepatide is often considered more potent, some individuals may notice a slight increase in hunger during the first few weeks after switching to semaglutide

These include psychobiotics, fecal microbiota transplantation, and dietary modifications such as Mediterranean diet and high-fiber intake

Average additional weight loss over 3-6 months was 4-7% of body weight, on top of the previous GLP-1 loss

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American Chemical Society (ACS)