Burks et al[34] has shown that losartan, an inhibitor of the angiotensin II type 1 receptor (AT1), was able to combat disuse atrophy in aged mice that were subjected to hindlimb immobilization, and this protective mechanism was due to an increased activation of the Akt/mTOR pathway
However, the long-term treatment with GLP-1RAs may reduce the insulin levels in both T2DM (122) and prediabetic patients (123), owing to the glycemic normalization and increased insulin sensitivity in these patients
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With respect to these gene sets, we tested for significantly overrepresented Gene Ontology and KEGG terms using a conditional hyper-geometric test as implemented in the GOstats package (R Bioconductor)