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It is good for 60 days approximately 60 days once opened.

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Avoid repeated freeze-thaw cycles unless freezing in single-use aliquots

It may however take a few days or weeks (especially if addressing a B12 deficiency)

If these intermediates build up faster than the Krebs cycle can process them, they become highly toxic, effectively choking the mitochondria and halting the entire energy-producing apparatus

John Salerno, because they seek a physician who looks beyond symptoms to identify and treat the true cause of their illness