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Although pancreatic beta cells normally exhibit low antioxidant activity, HNG was shown to enhance glucose oxidation, increase ATP levels, and elevate reactive oxygen species (ROS) without damaging mitochondrial membranes

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3 PNAS (1992) Dermorphin-related peptides activate two mu opioid receptor subtypes that modulate antinociception and catalepsy in the ratNegri, Erspamer, Severini, Potenza, Melchiorri & Erspamer (PMID 1353890)