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Peripheral GLP-1 or GLP-1RAs may interact with appetite-regulating regions of the brain via gaps in the blood-brain barrier, via tanycyte uptake, or indirectly via the nodose ganglia
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This is a very exciting development for people who are experiencing MASH, says Ani Kardashian, MD, an assistant professor and hepatologist with Keck Medicine at the University of Southern California in Los Angeles
There are other variables as mentioned, but this will get you in the "ball park"