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By surviving the harsh environment of the digestive tract without specialized enhancers, it offers a level of lifestyle flexibility previously thought impossible in this drug class

Semaglutide should not be used in patients with a history of suicidal attempts or active suicidal ideation

Rodbard HW, Rosenstock J, Canani LH et al (2019) Oral semaglutide versus empagliflozin in patients with type 2 diabetes uncontrolled on metformin: the PIONEER 2 trial

Peer review Peer review information Nature Medicine thanks Anke Hinney, Edra London and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Frequent or high-dose use can increase oxidative stress and, in some cases, cause liver injuryespecially when combined with alcohol or preexisting liver strain

long term effects on a breastfed infant are unknown