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Weight loss interventions that improve insulin sensitivitywhether through lifestyle modification, bariatric surgery, or pharmacotherapycan reduce hyperinsulinemia and subsequently decrease androgen excess, potentially improving acne in hormonally-driven cases

The association between weight-promoting medication use and weight gain in postmenopausal women: findings from the Women's Health Initiative

Under hypoxic conditions, cells activate adaptive responses mediated by hypoxia-inducible factor-1 (HIF-1), which regulates genes involved in angiogenesis, cell survival, and glucose metabolism

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Repeat courses can be run if a new injury occurs or symptoms recur after the initial course

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