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Both the exendin-P5 and oxyntomodulin bound complexes also exhibited less persistent interactions between ICL2 and the N and hns1/S1 region of G s and between the N-terminal portion of H8 with G , whereas the remainder of interactions were largely consistent across the different complexes (Supplemental Figure 13, Supplemental Tables 4-5)

Thats why many women find that traditional weight-loss strategies stop working during menopause