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Li D, Kou Y, Gao Y, Liu S, Yang P, Hasegawa T, et al

If the glutathione isn't protected from your stomach acid, you are essentially paying for expensive amino acids that won't have a significant impact on your melanin levels

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As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication

UV radiation, pollution, stress, and poor diet all generate free radicals that break down collagen and damage skin cells

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