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Intracellular GSH depletion is regarded as an early step of apoptosis as it occurs before loss of mitochondrial integrity, cytochrome c release, and activation of caspases [8]

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It is usually manifested as a diffuse, irregular, dark brown mucosal discoloration on the right side of the cecum and colon, which is often compared to the skin of crocodiles or snakes.36 In severe cases, all of the colonic mucosa of the external rectum is black

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Obesity, a poor diet, and lack of exercise are the main causes of the rise in newly diagnosed Type 1 and Type 2 diabetes cases