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GLP-2R activation reduced the expression of macrophage-dependent cytokines and LPS-induced inflammation in human islets (Fuchs et al., 2023), while loss of Glp-2r signaling in mice activated hepatic stellate cells and exacerbated diet-induced steatohepatitis (Fuchs et al., 2020)

Preclinical studies exploring the synergistic effects of such combinations are also essential for advancing this approach