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It is reasonable to hypothesize that retatrutide, like every drug in this class, will require continued use to preserve its effect, but that expectation is an extrapolation from class behavior rather than a demonstrated finding for this specific molecule

However, GLP-1 inhibitors have a long half-life approximately five weeks

doi: 10.1016/j.fertnstert.2012.11.045 148 HomaSTVassiliouAMStoneJKilleenAPDawkinsAXieJet al

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Because of this short half-life, clinical experts often recommend splitting the daily dose (e.g., taking half in the morning and half in the evening) to maintain steady, round-the-clock antioxidant levels in the bloodstream

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