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FcRn antagonism by use of IVIg and an IgG1 mAb specific for rat FcRn has been shown to prevent this disease and protect the fetus in disease modeling studies in mice [348, 349], suggesting a potential therapeutic avenue for FcRn antagonism in the clinic for this and similar diseases

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Sermorelin does not carry thyroid-specific contraindications, but growth hormone can alter thyroid hormone conversion (T4 to T3), requiring TSH monitoring in patients on levothyroxine replacement

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Activation of the NLRP3 inflammasome is often triggered by environmental allergens, leading to the cleavage of pro-IL1 into its active form via caspase-1, which subsequently promotes a pro-inflammatory milieu conducive to Th17 cell differentiation and neutrophil recruitment [150, 151]

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