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GLP-1 therapies in neurodegenerative diseases As described above, GLP-1RAs engage multiple convergent pathways implicated across NDDs, from proteostasis and mitochondrial quality control to neuroinflammation, synapse function, and gut-brain-immune interactions

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Indeed, daily oral administration of equal-lower doses (5 g/day) of l-ARG for shorter period (8 weeks) compared to the current study was found to significantly increase testosterone levels in diabetic patients with mildmoderate ED [16], potentially mediated by increased NO synthesis accompanied by vasodilation and increase of blood flow within the testis, resulting in improved testosterone production