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L-carnitine can bind with organic acids and the large amounts of acyl coenzyme derivatives produced in children with fatty acid metabolism disorder and turn them into water soluble acylcarnitine to be excreted through urine

& Dore, S

Diabetes 64(9):31723181

pH jumping method This is another solvent-free method that was first reported by Hauser and colleagues where SUVs were formed because of pH jump to MLVs [40, 48]