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Zepbound may increase hypoglycemia risk when used with insulin or sulfonylureas

The same finding had been reported by a prior larger meta-analysis (6,914 patients with overweight or obesity and T2DM) over 8 studies 184,185,189,190,191,192,193,194 , but only when the largest study that also included non-diabetic participants 193 was excluded in a sensitivity analysis 195

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Dose limits: Even in clinical trials, not everyone can tolerate or needs a 12 mg retatrutide dose each week